Endocrine Abstracts

The Na+/I− symporter (NIS), a glycoprotein expressed at the basolateral plasma membrane of thyroid epithelial cells, mediates active I− uptake for the biosynthesis of thyroid hormones and radioiodide transport for diagnosis and treatment in thyroid cancer. Our cloning of the NIS cDNA and generation of anti-NIS antibodies provided the basis to investigate the decrease in I− transport in thyroid cancer relative to hea...

The sodium/iodide transporter (NIS) mediates active I− uptake in thyroid, lactating breast, salivary gland, and stomach epithelial cells. NIS-mediated I− transport is electrogenic with a 2:1 Na+:I− stoichiometry, i.e. when NIS activity is measured electrophysiologically in NIS-expressing oocytes, inward positive currents are recorded upon addition of I− or other anions that are NIS substrates. Howev...

Objective: Serum TSH and thyroid hormone (TH) levels are routinely used as main measures of thyroid function. While these are highly valuable markers, it is becoming more evident that under specific conditions, their predictive power for tissue TH status is limited due to the highly complex nature of tissue-specific TH signaling. This led to a high demand for human tissue TH action markers that could allow the characterization of tissue TH economy. Therefore, our goal was to d...